The second BD4BO Group Meeting was hosted by Bayer AG in Berlin. The meeting saw representatives from DO->IT, HARMONY and BigData@Heart come together to discuss progress made so far as well as opportunities to collaborate and plan activities. DO->IT presented progress made to the disease specific projects in terms of establishing a cooperative working arrangement with ICHOM and the Comet Initiative for providing guidance on patient reported outcomes. A trial version of the knowledge repository being developed by DOàIT to store deliverables from BD4BO in a searchable and accessible format was presented. The feedback gathered will inform the construction of the real knowledge repository. Opportunities for collaboration were identified in HTA engagement and a memorandum of understanding between the projects will be explored.