The Innovative Medicines Initiative 2 (IMI2) Big Data for Better Outcomes (BD4BO) was launched in 2016 as an umbrella programme with the overall objective of realising the potential of Big Data in the context of European healthcare; for promoting innovative methods through harmonising, accessing and analysing data.

The BD4BO programme comprises several disease-specific projects focusing on Alzheimer’s disease- Real World Outcomes Across the Spectrum for Better Care (ROADMAP), hematologic malignancies- Healthcare Alliance for Resourceful Medicines Offensive against Neoplasm in Hematology (HARMONY), cardiovascular diseases- Big Data for Better Hearts BigData@Heart (BigData@Heart), and prostate cancer (PIONEER), with potential others at a later date. These disease-specific projects are supported by the Coordination and Support Action (DO-IT) as an overarching coordination structure (completed in 2019), and the European Health Data Networkand Evidence Network (EHDEN) project which will be a federated network of relevant data sources.

The Programme includes the following projects: